The Historic Galleano Winery was founded in 1927 by Domenico Galleano. Remarkably, the winery complex has remained largely unchanged to this day.

Galleano Winery is notable for being the last remaining bonded, Prohibition-era winery still owned and operated by its founding family at its original location in the Cucamonga Valley. The Galleano family takes great pride in the fact that the Cantu-Galleano Ranch complex is listed as a landmark on both the California and National Register of Historic Places.

Located in Mira Loma’s Wineville area, Galleano Winery retains much of its 1927 charm. It sits at the southern fringe of the Cucamonga Valley, a region made famous for winegrowing by Secondo Guasti, who, like Domenico, hailed from northern Italy’s Piedmont region. The name "Cucamonga" translates to "sandy place," aptly describing the alluvial plain that descends from the eastern slopes of the San Gabriel Mountains.

During the 1940s, the Cucamonga Valley boasted more than 45,000 acres dedicated to vineyards and approximately 60 wineries, showcasing the area’s rich viticultural history.